Non alcoholic Fatty Liver Disease


As the name suggest, non alcoholic fatty liver disease is accumulation of fat in the liver in the absence of significant amount of alcohol intake.

Normal liver contains some amount of fat, but if fat is > 10% of liver weight, it is diagnosed with fatty liver.

Predisposing factors are

  • Obesity
  • Diabetes
  • Dyslipidemia
  • Starvation

NAFLD is a disease with wide spectrum, which includes

Fatty liver
Fatty liver is the deposition of fat in liver, without inflammation and is the most benign disease of the spectrum with low risk of progression to severe disease

NASH (fatty liver with inflammation)
NASH is fat deposition with liver inflammation

These patients are at high risk for developing progressive liver diseases

Cirrhosis is the end stage manifestation of NAFLD

Following tests are done for diagnosis of NAFLD
  • LFT
  • USG abdomen showing enlarged liver and hyperechoic liver
  • FBS/serum insulin
  • Thyroid profile
  • Lipid profile
  • Liver biopsy in patients with persistent liver enzyme elevation

Treatment of NAFLD

  • Gradual weight reduction
  • Life style modification
  • Restricted calorie intake
  • Ursodeoxycholic acid and Vitamin E had shown the benefit in clinical trials